Naloxone
Naloxone: Reverses opiate overdose without the vomiting that naltrexone causes. In-game item, not medical advice.
Use, trade-offs and mechanics
Naloxone lowers the game's opiate level; it does not erase tolerance. This explains why an apparently successful overdose treatment can leave the character feeling worse. If remaining opiates were offsetting high tolerance, removing them makes reception more negative and can deepen withdrawal. Read reception and tolerance together rather than treating every opioid-related moodle as another overdose.
The documented injected effect removes four opiate levels for each milliliter, gradually at eight levels per second. Additional liquid extends the effect rather than increasing its speed. Naltrexone shares that antagonist effect, so combining them does not remove opiates faster. The community reference distinguishes naloxone because it lacks naltrexone's vomiting and unhappiness, despite being weaker per milliliter.
The fluid is not craftable and is not a recipe ingredient in the current reference. Its listed sources are a naloxone syringe and mini-barrels. The syringe interaction belongs to the health panel; drinking from a standard fluid container is a separate action. Once both tolerance and opiate levels reach zero, the antagonist effect clears. Keeping this distinction visible helps explain a change in moodles after an injection: the character's current reception can change without the underlying tolerance having been repaired. These are mechanics of an in-game object, not real-world dosage instructions.
Documented properties
| Property | Documented value | Status |
|---|---|---|
| type | Fluid | 1 community source |
| category | opiate antagonist | 1 community source |
| effect | −4 opiate levels per 1 mL, applied gradually at −8/s | 1 community source |
| dosage | Titrate per mL | 1 community source |
| risk | Can worsen withdrawal if opiate tolerance is still high | 1 community source |
| treats | Opioid overdose | 1 community source |
| obtain | Mini-barrel, naloxone syringe | 1 community source |
| craftable | No | 1 community source |


Questions
Where does this Naloxone information come from?
1 source · community wiki; store and publisher establish game context only. See the dated Sources table for the exact pages.
Related guides
Sources
| Source | Checked |
|---|---|
| Miraheze — Naloxone (liquid) | 2026-11-12 |